MolNFT v1 · #7203 · protein
The crystal structure of human placenta growth factor-1 (plgf-1), an angiogenic protein at 2.0A resolution
1FZV: “The crystal structure of human placenta growth factor-1 (plgf-1), an angiogenic protein at 2.0A resolution”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #7203 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1FZV
- Type
- protein
- Length
- 200 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Placenta growth factor
- UniProt
- P49763
- Pockets
- 1 · best druggability 0.30
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Placenta growth factor | protein | 100 | 11% helix, 56% strand | P49763 |
Ligands and binding sites
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.30 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1370 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1FZV · The crystal structure of human placenta growth factor-1 (plgf-1), an angiogenic protein… · the same entry in another collection · chain A against A, TM-score 1.00
- P49763 · AlphaFold monomer V2.0 prediction for placenta growth factor (P49763) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49763
- Elsewhere: RCSB PDB 1FZV · PDBe 1FZV · UniProt P49763
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