MolNFT v1 · #71945 · protein

X-ray structure of diguanylate CYCLASE/PHOSPHODIESTERASE from caldicellulosiruptor saccharolyticus, northeast structural genomics consortium target CLR27C

3MTK: “X-ray structure of diguanylate CYCLASE/PHOSPHODIESTERASE from caldicellulosiruptor saccharolyticus, northeast…”. X-ray diffraction, 1 pocket (best druggability 0.82). MolNFT v1 #71945 on GenesisL1: 3D structure, binding sites and…

PDB: 3MTK
Type: protein
Length: 325 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Diguanylate CYCLASE/PHOSPHODIESTERASE
UniProt: A4XHQ4
Pockets: 1 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Diguanylate CYCLASE/PHOSPHODIESTERASE	protein	163	47% helix, 26% strand	A4XHQ4
B	Diguanylate CYCLASE/PHOSPHODIESTERASE	protein	162	46% helix, 25% strand	A4XHQ4

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1176	0.82	0.83	72	empty

Interfaces

1 interface between chains.

A–B · 1008 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 modified (engineered).

Compared structures

3MTK · X-Ray Structure of Diguanylate cyclase/phosphodiesterase from Caldicellulosiruptor… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A4XHQ4
Elsewhere: RCSB PDB 3MTK · PDBe 3MTK · UniProt A4XHQ4

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