MolNFT v1 · #71944 · protein

The crystal structure of a homoserine dehydrogenase from thiobacillus denitrificans to 2.15A

3MTJ: “The crystal structure of a homoserine dehydrogenase from thiobacillus denitrificans to 2.15A”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.57). MolNFT v1 #71944 on GenesisL1: 3D structure, binding sites and…

PDB: 3MTJ
Type: protein
Length: 431 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Homoserine dehydrogenase
EC: 1.1.1.3
UniProt: Q3SKI5
Ligands: SO4
Pockets: 5 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Homoserine dehydrogenase (EC 1.1.1.3)	protein	431	42% helix, 24% strand	Q3SKI5

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	337	0.57	0.76	44	empty
2	141	0.57	0.83	21	empty
3	78	0.40	0.79	19	empty
4	97	0.38	0.75	22	SO4
5	67	0.34	0.76	18	empty

Modifications

Observed in the structure: 9 modified (engineered).

Compared structures

3MTJ · The Crystal Structure of a Homoserine Dehydrogenase from Thiobacillus denitrificans to… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3SKI5
Elsewhere: RCSB PDB 3MTJ · PDBe 3MTJ · UniProt Q3SKI5

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