MolNFT v1 · #71943 · protein
The crystal structure of a rRNA methylase from streptococcus thermophilus to 1.95A
3MTI: “The crystal structure of a rRNA methylase from streptococcus thermophilus to 1.95A”. X-ray diffraction, 3 pockets (best druggability 0.35). MolNFT v1 #71943 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3MTI
- Type
- protein
- Length
- 346 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RRNA methylase
- UniProt
- Q5M2Z6
- Pockets
- 3 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RRNA methylase | protein | 166 | 38% helix, 30% strand | Q5M2Z6 |
| B | RRNA methylase | protein | 180 | 33% helix, 28% strand | Q5M2Z6 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 110 | 0.35 | 0.73 | 27 | empty |
| 2 | 74 | 0.31 | 0.74 | 21 | empty |
| 3 | 68 | 0.29 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1381 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 modified (engineered).
Compared structures
- 3MTI · The Crystal Structure of a rRNA Methylase from Streptococcus thermophilus to 1.95A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5M2Z6
- Elsewhere: RCSB PDB 3MTI · PDBe 3MTI · UniProt Q5M2Z6
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