MolNFT v1 · #71808 · protein
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes
3MP7 · Preprotein translocase subunit secy: “Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes”. X-ray diffraction, 6 pockets (best druggability 0.77). MolNFT v1 #71808 on GenesisL1…
- PDB
- 3MP7
- Type
- protein
- Length
- 441 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Preprotein translocase subunit secy; Preprotein translocase subunit sece
- UniProt
- Q8U019, Q8TZK2
- Pockets
- 6 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Preprotein translocase subunit secy | protein | 387 | 57% helix, 2% strand | Q8U019 |
| B | Preprotein translocase subunit sece | protein | 54 | 74% helix, 0% strand | Q8TZK2 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1093 | 0.77 | 0.79 | 108 | empty |
| 2 | 223 | 0.58 | 0.79 | 27 | empty |
| 3 | 153 | 0.53 | 0.79 | 21 | empty |
| 4 | 218 | 0.52 | 0.76 | 26 | empty |
| 5 | 77 | 0.35 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1668 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3MP7 · Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8U019 · AlphaFold monomer V2.0 prediction for protein translocase subunit secy (Q8U019) · a predicted model of the same protein · chain A against A, TM-score 0.84
- Q8TZK2 · AlphaFold monomer V2.0 prediction for protein translocase subunit sece (Q8TZK2) · a predicted model of the same protein · chain B against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8U019
- Every structure of UniProt Q8TZK2
- Elsewhere: RCSB PDB 3MP7 · PDBe 3MP7 · UniProt Q8U019 · UniProt Q8TZK2
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