MolNFT v1 · #71720 · protein

Crystal structure of the globular tail of MYO4P

3MMI · Myosin-4: “Crystal structure of the globular tail of MYO4P”. X-ray diffraction, 12 pockets (best druggability 0.58). MolNFT v1 #71720 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3MMI
Type: protein
Length: 672 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin-4
UniProt: P32492
Pockets: 12 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myosin-4	protein	326	72% helix, 1% strand	P32492
B	Myosin-4	protein	346	71% helix, 1% strand	P32492

Pockets

12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	384	0.58	0.75	36	empty
2	258	0.56	0.77	31	empty
3	53	0.53	0.88	20	empty
4	140	0.46	0.77	17	empty
5	126	0.44	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 1569 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

3MMI · Crystal structure of the globular tail of Myo4p · the same entry in another collection · chain A against A, TM-score 1.00
P32492 · AlphaFold monomer V2.0 prediction for myosin-4 (P32492) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32492
Elsewhere: RCSB PDB 3MMI · PDBe 3MMI · UniProt P32492

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