MolNFT v1 · #71696 · protein
Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a ZAM18 V3 peptide
3MLU · Human monoclonal anti-HIV-1 GP120 V3 antibody 2557 Fab…: “Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a ZAM18 V3 peptide”. X-ray diffraction, 4 pockets (best druggability 0.47). MolNFT v1 #71696 on GenesisL1: 3D…
- PDB
- 3MLU
- Type
- protein
- Length
- 452 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human monoclonal anti-HIV-1 GP120 V3 antibody 2557 Fab light chain; Human monoclonal…
- UniProt
- Q9J0Z7
- Pockets
- 4 · best druggability 0.47
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Human monoclonal anti-HIV-1 GP120 V3 antibody 2557 Fab light chain | protein | 218 | 6% helix, 46% strand | — |
| H | Human monoclonal anti-HIV-1 GP120 V3 antibody 2557 Fab heavy chain | protein | 220 | 5% helix, 53% strand | — |
| P | HIV-1 GP120 third variable region (V3) crown | protein | 14 | 0% helix, 0% strand | Q9J0Z7 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 230 | 0.47 | 0.74 | 32 | empty |
| 2 | 82 | 0.44 | 0.80 | 12 | empty |
| 3 | 88 | 0.39 | 0.77 | 19 | empty |
| 4 | 84 | 0.32 | 0.73 | 14 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1851 Ų buried · 11 hydrogen bonds · protein-protein
- H–P · 474 Ų buried · 8 hydrogen bonds · protein-protein
- L–P · 382 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3MLU · Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a ZAM18 V3 peptide · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9J0Z7
- Elsewhere: RCSB PDB 3MLU · PDBe 3MLU · UniProt Q9J0Z7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.