MolNFT v1 · #71662 · protein

Structure of a cation-bound multidrug and toxin compound extrusion (mate) transporter

3MKT · Multi antimicrobial extrusion protein (NA(+)/DRUG…: “Structure of a cation-bound multidrug and toxin compound extrusion (mate) transporter”. X-ray diffraction, 12 pockets (best druggability 0.86). MolNFT v1 #71662 on GenesisL1: 3D…

PDB: 3MKT
Type: protein
Length: 920 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multi antimicrobial extrusion protein (NA(+)/DRUG antiporter) mate-like mdr efflux pump
UniProt: C3NQD8
Pockets: 12 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Multi antimicrobial extrusion protein (NA(+)/DRUG antiporter) mate-like mdr efflux pump	protein	460	74% helix, 0% strand	C3NQD8

Pockets

12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1200	0.86	0.86	112	empty
2	1166	0.86	0.86	121	empty
3	461	0.73	0.82	68	empty
4	324	0.67	0.81	48	empty
5	94	0.46	0.80	21	empty

Interfaces

1 interface between chains.

A–B · 369 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

3MKT · Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C3NQD8
Elsewhere: RCSB PDB 3MKT · PDBe 3MKT · UniProt C3NQD8

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