MolNFT v1 · #71606 · protein
Crystal structure of HL4E10 Fab, a hamster ab stimulatory for gammadelta T cells
3MJ8 · Stimulatory hamster antibody HL4E10 Fab light chain: “Crystal structure of HL4E10 Fab, a hamster ab stimulatory for gammadelta T cells”. X-ray diffraction, 8 pockets (best druggability 0.57). MolNFT v1 #71606 on GenesisL1: 3D…
- PDB
- 3MJ8
- Type
- protein
- Length
- 840 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stimulatory hamster antibody HL4E10 Fab light chain; Stimulatory hamster antibody HL4E10…
- Pockets
- 8 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, A | Stimulatory hamster antibody HL4E10 Fab light chain | protein | 209 | 5% helix, 55% strand | — |
| H, B | Stimulatory hamster antibody HL4E10 Fab heavy chain | protein | 211 | 6% helix, 53% strand | — |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 413 | 0.57 | 0.74 | 64 | empty |
| 2 | 310 | 0.52 | 0.74 | 48 | empty |
| 3 | 109 | 0.41 | 0.77 | 23 | empty |
| 4 | 95 | 0.37 | 0.75 | 19 | empty |
| 5 | 108 | 0.37 | 0.75 | 27 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1804 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1773 Ų buried · 14 hydrogen bonds · protein-protein
- L–A · 246 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 3MJ8 · Crystal structure of HL4E10 Fab, a hamster Ab stimulatory for gammadelta T cells · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3MJ8 · PDBe 3MJ8
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