MolNFT v1 · #71379 · protein
Anti-beta-amyloid antibody C706 Fab in space group P21
3MCL · C706 monoclonal light chain: “Anti-beta-amyloid antibody C706 Fab in space group P21”. X-ray diffraction, 3 pockets (best druggability 0.66). MolNFT v1 #71379 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3MCL
- Type
- protein
- Length
- 437 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- C706 monoclonal light chain; C706 monoclonal heavy chain
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | C706 monoclonal light chain | protein | 209 | 6% helix, 54% strand | — |
| H | C706 monoclonal heavy chain | protein | 228 | 8% helix, 51% strand | — |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 715 | 0.66 | 0.75 | 68 | empty |
| 2 | 396 | 0.57 | 0.75 | 44 | empty |
| 3 | 59 | 0.54 | 0.89 | 20 | empty |
Interfaces
1 interface between chains.
- L–H · 1656 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 1 modified (disulfide, cyclization).
Compared structures
- 3MCL · Anti-beta-amyloid antibody c706 fab in space group P21 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3MCL · PDBe 3MCL
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