MolNFT v1 · #71374 · protein

Three-dimensional structure of a light chain dimer crystallized in water. conformational flexibility of a molecule in two crystal forms

3MCG · Immunoglobulin lambda dimer mcg (light chain): “Three-dimensional structure of a light chain dimer crystallized in water. conformational flexibility of a…”. X-ray diffraction, 9 pockets (best druggability 0.72). MolNFT v1 #71374 on…

PDB: 3MCG
Type: protein
Length: 432 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Immunoglobulin lambda dimer mcg (light chain)
Pockets: 9 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
1, 2	Immunoglobulin lambda dimer mcg (light chain)	protein	216	6% helix, 41% strand	—

Pockets

9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	451	0.72	0.82	49	empty
2	519	0.61	0.74	56	empty
3	69	0.44	0.81	19	empty
4	66	0.43	0.82	18	empty
5	112	0.43	0.77	23	empty

Interfaces

1 interface between chains.

1–2 · 1731 Å² buried · 22 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide, 2 modified (disulfide, cyclization).

Compared structures

3MCG · Three-dimensional structure of a light chain dimer crystallized in water. conformational… · the same entry in another collection · chain 1 against 1, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3MCG · PDBe 3MCG

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