MolNFT v1 · #71323 · protein
Structure of the newcastle disease virus F protein in the post-fusion conformation
3MAW · Fusion glycoprotein F0: “Structure of the newcastle disease virus F protein in the post-fusion conformation”. X-ray diffraction, 2 ligands (NAG, NDG), 7 pockets (best druggability 0.42). MolNFT v1 #71323 on GenesisL1: 3D structure…
- PDB
- 3MAW
- Type
- protein
- Length
- 836 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F0
- UniProt
- P12572
- Ligands
- NAG, NDG
- Pockets
- 7 · best druggability 0.42
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Fusion glycoprotein F0 | protein | 418 | 38% helix, 23% strand | P12572 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.42 | 0.81 | 12 | empty |
| 2 | 69 | 0.39 | 0.79 | 14 | empty |
| 3 | 77 | 0.36 | 0.76 | 14 | empty |
| 4 | 90 | 0.36 | 0.75 | 14 | empty |
| 5 | 67 | 0.36 | 0.77 | 18 | empty |
Modifications
Observed in the structure: 10 disulfide, 6 glycan (disulfide, N-glycosylation).
Compared structures
- 3MAW · Structure of the Newcastle disease virus F protein in the post-fusion conformation · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12572
- Elsewhere: RCSB PDB 3MAW · PDBe 3MAW · UniProt P12572
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