MolNFT v1 · #71179 · protein

F80A mutant of the urea transporter from desulfovibrio vulgaris

3M6E · Putative urea transporter: “F80A mutant of the urea transporter from desulfovibrio vulgaris”. X-ray diffraction, 1 ligand (AU), 2 pockets (best druggability 0.61). MolNFT v1 #71179 on GenesisL1: 3D structure, binding sites and…

PDB: 3M6E
Type: protein
Length: 333 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative urea transporter
UniProt: Q72CX3
Ligands: AU
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative urea transporter	protein	333	70% helix, 1% strand	Q72CX3

Ligands and binding sites

AU · Gold ion · metal · 9 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	332	0.61	0.78	33	empty
2	237	0.60	0.80	31	AU

Compared structures

3M6E · F80A mutant of the Urea Transporter from Desulfovibrio Vulgaris · the same entry in another collection · chain A against A, TM-score 1.00
Q72CX3 · AlphaFold monomer V2.0 prediction for urea transporter DVU1160 (Q72CX3) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q72CX3
Elsewhere: RCSB PDB 3M6E · PDBe 3M6E · UniProt Q72CX3

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