MolNFT v1 · #71165 · protein
Crystal structure of the mutant V182A,I199A of orotidine 5'- monophosphate decarboxylase from methanobacterium thermoautotrophicum
3M5X · Orotidine 5'-phosphate decarboxylase: “Crystal structure of the mutant V182A,I199A of orotidine 5'- monophosphate decarboxylase from…”. X-ray diffraction, 2 pockets (best druggability 0.67). MolNFT v1 #71165 on GenesisL1: 3D…
- PDB
- 3M5X
- Type
- protein
- Length
- 424 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Orotidine 5'-phosphate decarboxylase
- EC
- 4.1.1.23
- UniProt
- O26232
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) | protein | 212 | 50% helix, 19% strand | O26232 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 262 | 0.67 | 0.83 | 30 | empty |
| 2 | 278 | 0.65 | 0.81 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 1702 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 3M5X · Crystal structure of the mutant V182A,I199A of orotidine 5'-monophosphate decarboxylase… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O26232
- Elsewhere: RCSB PDB 3M5X · PDBe 3M5X · UniProt O26232
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