MolNFT v1 · #71162 · protein
Crystal structure of phosphoserine aminotransferase from campylobacter jejuni
3M5U: “Crystal structure of phosphoserine aminotransferase from campylobacter jejuni”. X-ray diffraction, 5 pockets (best druggability 0.69). MolNFT v1 #71162 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3M5U
- Type
- protein
- Length
- 716 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoserine aminotransferase
- EC
- 2.6.1.52
- UniProt
- Q9PIH3
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phosphoserine aminotransferase (EC 2.6.1.52) | protein | 358 | 41% helix, 17% strand | Q9PIH3 |
Ligands and binding sites
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 2 copies · chains A, B
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 415 | 0.69 | 0.81 | 48 | MES |
| 2 | 415 | 0.67 | 0.80 | 51 | MES |
| 3 | 119 | 0.37 | 0.73 | 25 | empty |
| 4 | 65 | 0.31 | 0.75 | 21 | empty |
| 5 | 52 | 0.28 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2228 Ų buried · 36 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified, 1 disulfide (engineered, disulfide).
Compared structures
- 3M5U · Crystal Structure of Phosphoserine Aminotransferase from Campylobacter jejuni · the same entry in another collection · chain A against A, TM-score 1.00
- Q9PIH3 · AlphaFold monomer V2.0 prediction for phosphoserine aminotransferase (Q9PIH3) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9PIH3
- Elsewhere: RCSB PDB 3M5U · PDBe 3M5U · UniProt Q9PIH3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.