MolNFT v1 · #71096 · protein

Crystal structure of mouse PACSIN3 bar domain mutant

3M3W · Protein kinase C and casein kinase II substrate protein 3: “Crystal structure of mouse PACSIN3 bar domain mutant”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #71096 on GenesisL1: 3D structure, binding sites and…

PDB: 3M3W
Type: protein
Length: 566 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein kinase C and casein kinase II substrate protein 3
UniProt: Q99JB8
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein kinase C and casein kinase II substrate protein 3	protein	280	81% helix, 0% strand	Q99JB8
B	Protein kinase C and casein kinase II substrate protein 3	protein	286	72% helix, 1% strand	Q99JB8

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	153	0.55	0.81	24	empty
2	78	0.50	0.84	23	empty

Interfaces

1 interface between chains.

A–B · 4498 Å² buried · 47 hydrogen bonds · protein-protein

Compared structures

3M3W · Crystal structure of mouse PACSIN3 BAR domain mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q99JB8 · AlphaFold monomer V2.0 prediction for protein kinase C and casein kinase II substrate… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99JB8
Elsewhere: RCSB PDB 3M3W · PDBe 3M3W · UniProt Q99JB8

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