MolNFT v1 · #70975 · protein

Crystal structure of putative farnesyl diphosphate synthase from rhodobacter capsulatus

3M0G: “Crystal structure of putative farnesyl diphosphate synthase from rhodobacter capsulatus”. X-ray diffraction, 8 pockets (best druggability 0.65). MolNFT v1 #70975 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3M0G
Type: protein
Length: 532 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Farnesyl diphosphate synthase
UniProt: Q9KWR7
Pockets: 8 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 75% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Farnesyl diphosphate synthase	protein	264	75% helix, 2% strand	Q9KWR7
B	Farnesyl diphosphate synthase	protein	268	76% helix, 1% strand	Q9KWR7

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	385	0.65	0.79	53	empty
2	405	0.64	0.78	50	empty
3	55	0.53	0.88	13	empty
4	78	0.41	0.79	22	empty
5	75	0.40	0.79	18	empty

Interfaces

1 interface between chains.

A–B · 1715 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 14 modified (engineered).

Compared structures

3M0G · CRYSTAL STRUCTURE OF putative farnesyl diphosphate synthase from Rhodobacter capsulatus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9KWR7
Elsewhere: RCSB PDB 3M0G · PDBe 3M0G · UniProt Q9KWR7

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