MolNFT v1 · #70899 · protein

Crystal structure of mutant D471N of the periplasmic domain of cadc

3LY9 · Transcriptional activator cadc: “Crystal structure of mutant D471N of the periplasmic domain of cadc”. X-ray diffraction, 4 pockets (best druggability 0.81). MolNFT v1 #70899 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 3LY9
Type: protein
Length: 322 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional activator cadc
UniProt: P23890
Pockets: 4 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 56% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional activator cadc	protein	322	56% helix, 12% strand	P23890

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	167	0.81	0.96	34	empty
2	83	0.39	0.78	17	empty
3	103	0.38	0.75	21	empty
4	79	0.37	0.77	16	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3LY9 · Crystal structure of mutant D471N of the periplasmic domain of CadC · the same entry in another collection · chain A against A, TM-score 1.00
P23890 · AlphaFold monomer V2.0 prediction for transcriptional activator cadc (P23890) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23890
Elsewhere: RCSB PDB 3LY9 · PDBe 3LY9 · UniProt P23890

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