MolNFT v1 · #70719 · protein + DNA
Crystal structure of dest in complex with duplex DNA
3LSR: “Crystal structure of dest in complex with duplex DNA”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.78). MolNFT v1 #70719 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3LSR
- Type
- protein + DNA
- Length
- 219 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dest; DNA (27-mer)
- UniProt
- Q9HUS3
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dest | protein | 192 | 77% helix, 0% strand | Q9HUS3 |
| B | DNA (27-mer) | dna | 27 | — | — |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 329 | 0.78 | 0.88 | 35 | SO4 |
Interfaces
1 interface between chains.
- A–B · 435 Ų buried · 12 hydrogen bonds · protein-nucleic
Compared structures
- 3LSR · Crystal structure of DesT in complex with duplex DNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HUS3
- Elsewhere: RCSB PDB 3LSR · PDBe 3LSR · UniProt Q9HUS3
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