MolNFT v1 · #70571 · protein
C-terminal domain of human heat shock 70KDA protein 1B.
3LOF · Heat shock 70 kda protein 1: “C-terminal domain of human heat shock 70KDA protein 1B.”. X-ray diffraction, 5 pockets (best druggability 0.63). MolNFT v1 #70571 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3LOF
- Type
- protein
- Length
- 485 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock 70 kda protein 1
- UniProt
- P08107
- Pockets
- 5 · best druggability 0.63
Structure
x-ray diffraction · 6 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock 70 kda protein 1 | protein | 84 | 83% helix, 2% strand | P08107 |
| B | Heat shock 70 kda protein 1 | protein | 80 | 79% helix, 0% strand | P08107 |
| C | Heat shock 70 kda protein 1 | protein | 80 | 78% helix, 0% strand | P08107 |
| D | Heat shock 70 kda protein 1 | protein | 79 | 84% helix, 0% strand | P08107 |
| E | Heat shock 70 kda protein 1 | protein | 82 | 77% helix, 0% strand | P08107 |
| F | Heat shock 70 kda protein 1 | protein | 80 | 80% helix, 0% strand | P08107 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 255 | 0.63 | 0.81 | 33 | empty |
| 2 | 61 | 0.35 | 0.77 | 11 | empty |
| 3 | 79 | 0.34 | 0.75 | 14 | empty |
| 4 | 89 | 0.33 | 0.73 | 20 | empty |
| 5 | 65 | 0.33 | 0.76 | 14 | empty |
Interfaces
9 interfaces between chains.
- E–F · 773 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 755 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 677 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 406 Ų buried · 8 hydrogen bonds · protein-protein
- C–E · 397 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 3LOF · C-terminal domain of human heat shock 70kDa protein 1B. · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08107
- Elsewhere: RCSB PDB 3LOF · PDBe 3LOF · UniProt P08107
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.