MolNFT v1 · #70559 · protein
The crystal structure of a conserved functionally unknown protein from colwellia psychrerythraea 34H.
3LO3 · Uncharacterized conserved protein: “The crystal structure of a conserved functionally unknown protein from colwellia psychrerythraea 34H.”. X-ray diffraction, 20 pockets (best druggability 0.86). MolNFT v1 #70559 on GenesisL1: 3D…
- PDB
- 3LO3
- Type
- protein
- Length
- 2,632 residues
- Chains
- 28
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized conserved protein
- UniProt
- Q484V4
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b | Uncharacterized conserved protein | protein | 94 | 38% helix, 37% strand | Q484V4 |
Ligands and binding sites
- GOL · Glycerol · additive · 4 copies · chains C, D, Q, O, P, T, U
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1038 | 0.86 | 0.87 | 118 | empty |
| 2 | 684 | 0.85 | 0.89 | 97 | empty |
| 3 | 809 | 0.84 | 0.86 | 100 | GOL |
| 4 | 1183 | 0.80 | 0.81 | 108 | GOL |
| 5 | 319 | 0.79 | 0.90 | 49 | empty |
Interfaces
76 interfaces between chains.
- C–D · 1370 Ų buried · 25 hydrogen bonds · protein-protein
- S–T · 1368 Ų buried · 27 hydrogen bonds · protein-protein
- W–X · 1363 Ų buried · 27 hydrogen bonds · protein-protein
- Y–Z · 1363 Ų buried · 24 hydrogen bonds · protein-protein
- K–L · 1361 Ų buried · 28 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 28 modified (engineered).
Compared structures
- 3LO3 · The crystal structure of a conserved functionally unknown protein from Colwellia… · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q484V4
- Elsewhere: RCSB PDB 3LO3 · PDBe 3LO3 · UniProt Q484V4
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