MolNFT v1 · #70509 · protein
Crystal structure of the sheath tail protein LIN1278 from listeria innocua, northeast structural genomics consortium target LKR115
3LML · LIN1278 protein: “Crystal structure of the sheath tail protein LIN1278 from listeria innocua, northeast structural genomics…”. X-ray diffraction, 20 pockets (best druggability 0.78). MolNFT v1 #70509 on GenesisL1: 3D structure…
- PDB
- 3LML
- Type
- protein
- Length
- 2,613 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LIN1278 protein
- UniProt
- Q92CB1
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 6 distinct chains · 31% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | LIN1278 protein | protein | 440 | 31% helix, 28% strand | Q92CB1 |
| B | LIN1278 protein | protein | 435 | 31% helix, 28% strand | Q92CB1 |
| C | LIN1278 protein | protein | 438 | 31% helix, 29% strand | Q92CB1 |
| D | LIN1278 protein | protein | 434 | 30% helix, 27% strand | Q92CB1 |
| E | LIN1278 protein | protein | 431 | 30% helix, 29% strand | Q92CB1 |
| F | LIN1278 protein | protein | 435 | 31% helix, 28% strand | Q92CB1 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 886 | 0.78 | 0.81 | 86 | empty |
| 2 | 939 | 0.78 | 0.80 | 97 | empty |
| 3 | 942 | 0.77 | 0.80 | 90 | empty |
| 4 | 732 | 0.73 | 0.79 | 75 | empty |
| 5 | 1128 | 0.72 | 0.76 | 105 | empty |
Interfaces
9 interfaces between chains.
- A–B · 761 Ų buried · 0 hydrogen bonds · protein-protein
- E–F · 742 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 623 Ų buried · 5 hydrogen bonds · protein-protein
- D–F · 559 Ų buried · 3 hydrogen bonds · protein-protein
- C–F · 187 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified (engineered).
Compared structures
- 3LML · Crystal Structure of the sheath tail protein Lin1278 from Listeria innocua, Northeast… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92CB1
- Elsewhere: RCSB PDB 3LML · PDBe 3LML · UniProt Q92CB1
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