MolNFT v1 · #70476 · protein

Crystal structure of the stas domain of motor protein prestin (anion transporter SLC26A5)

3LLO: “Crystal structure of the stas domain of motor protein prestin (anion transporter SLC26A5)”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #70476 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3LLO
Type: protein
Length: 132 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prestin
UniProt: Q9EPH0
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prestin	protein	132	36% helix, 21% strand	Q9EPH0

Ligands and binding sites

BOG · octyl beta-D-glucopyranoside · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	94	0.61	0.87	19	empty
2	63	0.43	0.81	14	empty
3	85	0.33	0.74	15	BOG

Compared structures

3LLO · Crystal structure of the STAS domain of motor protein prestin (anion transporter SLC26A5) · the same entry in another collection · chain A against A, TM-score 1.00
Q9EPH0 · AlphaFold monomer V2.0 prediction for prestin (Q9EPH0) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9EPH0
Elsewhere: RCSB PDB 3LLO · PDBe 3LLO · UniProt Q9EPH0

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