MolNFT v1 · #7038 · protein

Yeast initiation factor 4A

1FUU: “Yeast initiation factor 4A”. X-ray diffraction, 3 pockets (best druggability 0.34). MolNFT v1 #7038 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1FUU
Type: protein
Length: 595 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Yeast initiation factor 4A
UniProt: P10081
Pockets: 3 · best druggability 0.34

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Yeast initiation factor 4A	protein	215	46% helix, 15% strand	P10081
B	Yeast initiation factor 4A	protein	380	37% helix, 18% strand	P10081

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	92	0.34	0.74	19	empty
2	67	0.27	0.72	15	empty
3	61	0.27	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 292 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 20 modified (engineered).

Compared structures

1FUU · Yeast initiation factor 4A · the same entry in another collection · chain A against A, TM-score 1.00
P10081 · AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase EIF4A (P10081) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10081
Elsewhere: RCSB PDB 1FUU · PDBe 1FUU · UniProt P10081

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