MolNFT v1 · #70361 · protein

Crystal structure of the extracellular domain of the putative histidine kinase MMHK1S-Z2

3LI9 · Hypothetical sensory transduction histidine kinase: “Crystal structure of the extracellular domain of the putative histidine kinase MMHK1S-Z2”. X-ray diffraction, 2 pockets (best druggability 0.48). MolNFT v1 #70361 on GenesisL1: 3D…

PDB: 3LI9
Type: protein
Length: 262 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypothetical sensory transduction histidine kinase
UniProt: Q8PSW8
Pockets: 2 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hypothetical sensory transduction histidine kinase	protein	262	34% helix, 29% strand	Q8PSW8

Ligands and binding sites

BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	118	0.48	0.79	18	BTB
2	119	0.42	0.75	26	empty

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

3LI9 · Crystal Structure of the extracellular domain of the putative histidine kinase mmHK1S-Z2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8PSW8
Elsewhere: RCSB PDB 3LI9 · PDBe 3LI9 · UniProt Q8PSW8

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