MolNFT v1 · #70284 · protein
Structure of plasmodium falciparum ornithine delta-aminotransferase
3LG0 · Ornithine aminotransferase: “Structure of plasmodium falciparum ornithine delta-aminotransferase”. X-ray diffraction, 12 pockets (best druggability 0.77). MolNFT v1 #70284 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3LG0
- Type
- protein
- Length
- 1,542 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ornithine aminotransferase
- EC
- 2.6.1.13
- UniProt
- Q07805
- Pockets
- 12 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ornithine aminotransferase (EC 2.6.1.13) | protein | 385 | 41% helix, 20% strand | Q07805 |
| C | Ornithine aminotransferase (EC 2.6.1.13) | protein | 385 | 40% helix, 20% strand | Q07805 |
| D | Ornithine aminotransferase (EC 2.6.1.13) | protein | 387 | 40% helix, 20% strand | Q07805 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1132 | 0.77 | 0.79 | 102 | empty |
| 2 | 571 | 0.71 | 0.80 | 60 | empty |
| 3 | 494 | 0.68 | 0.79 | 60 | empty |
| 4 | 589 | 0.64 | 0.75 | 54 | empty |
| 5 | 71 | 0.52 | 0.85 | 21 | empty |
Interfaces
4 interfaces between chains.
- C–D · 4121 Ų buried · 48 hydrogen bonds · protein-protein
- A–B · 4098 Ų buried · 50 hydrogen bonds · protein-protein
- A–D · 178 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 45 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3LG0 · Structure of Plasmodium falciparum ornithine delta-aminotransferase · the same entry in another collection · chain A against A, TM-score 1.00
- Q07805 · AlphaFold monomer V2.0 prediction for ornithine aminotransferase (Q07805) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07805
- Elsewhere: RCSB PDB 3LG0 · PDBe 3LG0 · UniProt Q07805
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