MolNFT v1 · #69985 · protein

Crystal structure of P120 catenin in complex with E-cadherin

3L6X · Catenin delta-1: “Crystal structure of P120 catenin in complex with E-cadherin”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.32). MolNFT v1 #69985 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3L6X
Type: protein
Length: 452 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Catenin delta-1; E-cadherin
UniProt: O60716
Ligands: SO4
Pockets: 2 · best druggability 0.32

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Catenin delta-1	protein	434	73% helix, 0% strand	O60716
B	E-cadherin	protein	18	17% helix, 0% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.32	0.74	13	empty
2	69	0.29	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 1239 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

3L6X · Crystal structure of p120 catenin in complex with E-cadherin · the same entry in another collection · chain A against A, TM-score 1.00
O60716 · AlphaFold monomer V2.0 prediction for catenin delta-1 (O60716) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60716
Elsewhere: RCSB PDB 3L6X · PDBe 3L6X · UniProt O60716

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.