MolNFT v1 · #69903 · protein
Structural basis of membrane-targeting by DOCK180
3L4C · Dedicator of cytokinesis protein 1: “Structural basis of membrane-targeting by DOCK180”. X-ray diffraction, 3 pockets (best druggability 0.39). MolNFT v1 #69903 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3L4C
- Type
- protein
- Length
- 357 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dedicator of cytokinesis protein 1
- UniProt
- Q14185
- Pockets
- 3 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dedicator of cytokinesis protein 1 | protein | 178 | 7% helix, 44% strand | Q14185 |
| B | Dedicator of cytokinesis protein 1 | protein | 179 | 9% helix, 43% strand | Q14185 |
Ligands and binding sites
- BME · Beta-mercaptoethanol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.39 | 0.77 | 17 | empty |
| 2 | 64 | 0.38 | 0.79 | 21 | empty |
| 3 | 75 | 0.32 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 207 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent (additive adduct).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14185
- Elsewhere: RCSB PDB 3L4C · PDBe 3L4C · UniProt Q14185
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