MolNFT v1 · #69727 · protein

C-terminal domain of murine FKBP25 rapamycin complex

3KZ7 · FK506-binding protein 3: “C-terminal domain of murine FKBP25 rapamycin complex”. X-ray diffraction, 1 ligand (RAP), 1 pocket (best druggability 0.38). MolNFT v1 #69727 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3KZ7
Type: protein
Length: 119 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: FK506-binding protein 3
EC: 5.2.1.8
UniProt: Q62446
Ligands: RAP
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	FK506-binding protein 3 (EC 5.2.1.8)	protein	119	11% helix, 35% strand	Q62446

Ligands and binding sites

RAP · Rapamycin immunosuppressant drug · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	80	0.38	0.76	14	empty

Compared structures

3KZ7 · C-terminal domain of Murine FKBP25 rapamycin complex · the same entry in another collection · chain A against A, TM-score 1.00
Q62446 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP3 (Q62446) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62446
Elsewhere: RCSB PDB 3KZ7 · PDBe 3KZ7 · UniProt Q62446

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