MolNFT v1 · #69536 · protein

Structure of the N-terminal brct domain of human microcephalin (MCPH1).

3KTF: “Structure of the N-terminal brct domain of human microcephalin (MCPH1).”. X-ray diffraction, 1 ligand (CL). MolNFT v1 #69536 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3KTF
Type: protein
Length: 282 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microcephalin
UniProt: Q8NEM0
Ligands: CL

Structure

x-ray diffraction · 3 distinct chains · 35% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Microcephalin	protein	97	34% helix, 20% strand	Q8NEM0
B	Microcephalin	protein	93	35% helix, 20% strand	Q8NEM0
C	Microcephalin	protein	92	35% helix, 22% strand	Q8NEM0

Ligands and binding sites

CL · Chloride ion · ion · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

2 interfaces between chains.

A–C · 422 Å² buried · 6 hydrogen bonds · protein-protein
A–B · 413 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

3KTF · Structure of the N-terminal BRCT domain of human microcephalin (MCPH1). · the same entry in another collection · chain A against A, TM-score 1.00
Q8NEM0 · AlphaFold monomer V2.0 prediction for microcephalin (Q8NEM0) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NEM0
Elsewhere: RCSB PDB 3KTF · PDBe 3KTF · UniProt Q8NEM0

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