MolNFT v1 · #69315 · protein + RNA

G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, tetragonal structure

3KMQ · 3D polymerase: “G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, tetragonal…”. X-ray diffraction, 2 pockets (best druggability 0.78). MolNFT v1 #69315 on GenesisL1: 3D structure…

PDB: 3KMQ
Type: protein + RNA
Length: 486 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3D polymerase; RNA (5'-R(P*GP*GP*GP*CP*C)-3'); RNA (5'-R(*GP*GP*CP*CP*C)-3')
EC: 2.7.7.48
UniProt: Q9QCE3
Pockets: 2 · best druggability 0.78

Structure

x-ray diffraction · 3 distinct chains · 40% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3D polymerase (EC 2.7.7.48)	protein	476	40% helix, 17% strand	Q9QCE3
B	RNA (5'-R(PGPGPGPCP*C)-3')	rna	5	—	—
C	RNA (5'-R(GPGPCPCP*C)-3')	rna	5	—	—

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1115	0.78	0.80	79	empty
2	159	0.67	0.88	29	empty

Interfaces

3 interfaces between chains.

A–B · 648 Å² buried · 20 hydrogen bonds · protein-nucleic
A–C · 616 Å² buried · 5 hydrogen bonds · protein-nucleic
B–C · 231 Å² buried · 23 hydrogen bonds · nucleic-nucleic

Compared structures

3KMQ · G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9QCE3
Elsewhere: RCSB PDB 3KMQ · PDBe 3KMQ · UniProt Q9QCE3

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.