MolNFT v1 · #69054 · protein
Crystal structure of the GLUA4 ligand-binding domain L651V mutant in complex with glutamate
3KEI · Glutamate receptor 4: “Crystal structure of the GLUA4 ligand-binding domain L651V mutant in complex with glutamate”. X-ray diffraction, 1 ligand (GLU), 4 pockets (best druggability 0.44). MolNFT v1 #69054 on GenesisL1: 3D structure…
- PDB
- 3KEI
- Type
- protein
- Length
- 514 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 4
- UniProt
- P19493
- Ligands
- GLU
- Pockets
- 4 · best druggability 0.44
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glutamate receptor 4 | protein | 257 | 38% helix, 21% strand | P19493 |
Ligands and binding sites
- GLU · Glutamic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 137 | 0.44 | 0.76 | 23 | empty |
| 2 | 126 | 0.41 | 0.75 | 21 | empty |
| 3 | 97 | 0.38 | 0.76 | 24 | empty |
| 4 | 75 | 0.33 | 0.75 | 15 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3KEI · Crystal Structure of the GluA4 Ligand-Binding domain L651V mutant in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P19493 · AlphaFold monomer V2.0 prediction for glutamate receptor 4 (P19493) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19493
- Elsewhere: RCSB PDB 3KEI · PDBe 3KEI · UniProt P19493
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