MolNFT v1 · #68998 · protein

Structure of formate channel

3KCV · Probable formate transporter 1: “Structure of formate channel”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #68998 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3KCV
Type: protein
Length: 2,510 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable formate transporter 1
UniProt: P0AC25
Pockets: 20 · best druggability 0.80

Structure

x-ray diffraction · 4 distinct chains · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Probable formate transporter 1	protein	250	77% helix, 0% strand	P0AC25
D	Probable formate transporter 1	protein	251	75% helix, 0% strand	P0AC25
E, F, G, H, I	Probable formate transporter 1	protein	252	75% helix, 0% strand	P0AC25
J	Probable formate transporter 1	protein	249	77% helix, 0% strand	P0AC25

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1100	0.80	0.80	103	empty
2	1116	0.80	0.81	91	empty
3	565	0.78	0.83	75	empty
4	825	0.75	0.78	92	empty
5	1093	0.74	0.77	89	empty

Interfaces

22 interfaces between chains.

I–J · 1655 Å² buried · 6 hydrogen bonds · protein-protein
F–J · 1652 Å² buried · 7 hydrogen bonds · protein-protein
A–E · 1627 Å² buried · 9 hydrogen bonds · protein-protein
F–G · 1612 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 1608 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

3KCV · Structure of formate channel · the same entry in another collection · chain J against J, TM-score 1.00
P0AC25 · AlphaFold monomer V2.0 prediction for probable formate transporter 1 (P0AC25) · a predicted model of the same protein · chain J against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0AC25
Elsewhere: RCSB PDB 3KCV · PDBe 3KCV · UniProt P0AC25

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