MolNFT v1 · #6893 · protein
Crystal structures of mutant (K296A) that abolish the dilysine interaction in the N-lobe of human transferrin
1FQF · Serotransferrin: “Crystal structures of mutant (K296A) that abolish the dilysine interaction in the N-lobe of human transferrin”. X-ray diffraction, 2 ligands (FE, CO3), 3 pockets (best druggability 0.74). MolNFT v1 #6893 on…
- PDB
- 1FQF
- Type
- protein
- Length
- 329 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serotransferrin
- UniProt
- P02787
- Ligands
- FE, CO3
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serotransferrin | protein | 329 | 34% helix, 21% strand | P02787 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 163 | 0.74 | 0.92 | 39 | empty |
| 2 | 106 | 0.39 | 0.75 | 21 | empty |
| 3 | 60 | 0.29 | 0.74 | 15 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1FQF · Crystal structures of mutant (K296A) that abolish the dilysine interaction in the N-lobe… · the same entry in another collection · chain A against A, TM-score 1.00
- P02787 · AlphaFold monomer V2.0 prediction for serotransferrin (P02787) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02787
- Elsewhere: RCSB PDB 1FQF · PDBe 1FQF · UniProt P02787
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