MolNFT v1 · #68692 · protein
Crystal structure of the catalytic core domain of human PHF8 complexed with alpha-ketoglutarate
3K3O · Phd finger protein 8: “Crystal structure of the catalytic core domain of human PHF8 complexed with alpha-ketoglutarate”. X-ray diffraction, 2 ligands (AKG, FE2), 3 pockets (best druggability 0.65). MolNFT v1 #68692 on GenesisL1: 3D…
- PDB
- 3K3O
- Type
- protein
- Length
- 350 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phd finger protein 8
- EC
- 1.14.11.-
- UniProt
- Q5JPR9
- Ligands
- AKG, FE2
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phd finger protein 8 (EC 1.14.11.-) | protein | 350 | 38% helix, 23% strand | Q5JPR9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 492 | 0.65 | 0.77 | 60 | AKG |
| 2 | 118 | 0.43 | 0.76 | 20 | empty |
| 3 | 55 | 0.27 | 0.73 | 13 | empty |
Compared structures
- 3K3O · Crystal structure of the catalytic core domain of human PHF8 complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5JPR9
- Elsewhere: RCSB PDB 3K3O · PDBe 3K3O · UniProt Q5JPR9
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