MolNFT v1 · #6836 · protein + DNA
Two human C-FOS:C-JUN:DNA complexes
1FOS · DNA (5'- D(*AP*AP*TP*GP*GP*AP*TP*GP*AP*GP*TP*CP*AP*TP*AP*GP*…: “Two human C-FOS:C-JUN:DNA complexes”. X-ray diffraction, 8 pockets (best druggability 0.77). MolNFT v1 #6836 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1FOS
- Type
- protein + DNA
- Length
- 314 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*AP*AP*TP*GP*GP*AP*TP*GP*AP*GP*TP*CP*AP*TP*AP*GP*GP*AP*GP*A)-3'); DNA (5'…
- UniProt
- P01100
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 6 distinct chains · 96% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | DNA (5'- D(*AP*AP*TP*GP*GP*AP*TP*GP*AP*GP*TP*CP*AP*TP*AP*GP*GP*AP*GP*A)-3') | dna | 20 | — | — |
| B, D | DNA (5'- D(*TP*TP*CP*TP*CP*CP*TP*AP*TP*GP*AP*CP*TP*CP*AP*TP*CP*CP*AP*T)-3') | dna | 20 | — | — |
| E | P55-C-fos proto-oncogene protein | protein | 60 | 95% helix, 0% strand | P01100 |
| F | C-jun proto-oncogene protein | protein | 57 | 96% helix, 0% strand | — |
| G | P55-C-fos proto-oncogene protein | protein | 59 | 97% helix, 0% strand | P01100 |
| H | C-jun proto-oncogene protein | protein | 58 | 95% helix, 0% strand | — |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 706 | 0.77 | 0.82 | 52 | empty |
| 2 | 231 | 0.75 | 0.90 | 25 | empty |
| 3 | 101 | 0.52 | 0.83 | 15 | empty |
| 4 | 132 | 0.47 | 0.78 | 17 | empty |
| 5 | 95 | 0.44 | 0.79 | 17 | empty |
Interfaces
19 interfaces between chains.
- E–F · 1247 Ų buried · 12 hydrogen bonds · protein-protein
- G–H · 1222 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 848 Ų buried · 89 hydrogen bonds · nucleic-nucleic
- A–B · 841 Ų buried · 87 hydrogen bonds · nucleic-nucleic
- D–G · 405 Ų buried · 3 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01100
- Elsewhere: RCSB PDB 1FOS · PDBe 1FOS · UniProt P01100
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