MolNFT v1 · #68241 · protein

Eed: a novel histone trimethyllysine binder within the eed-EZH2 polycomb complex

3JPX · Polycomb protein eed: “Eed: a novel histone trimethyllysine binder within the eed-EZH2 polycomb complex”. X-ray diffraction, 2 pockets (best druggability 0.78). MolNFT v1 #68241 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 3JPX
Type: protein
Length: 365 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polycomb protein eed; Histone peptide
UniProt: O75530
Pockets: 2 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polycomb protein eed	protein	359	6% helix, 47% strand	O75530
B	Histone peptide	protein	6	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	423	0.78	0.86	43	empty
2	103	0.40	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 448 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

3JPX · EED: A Novel Histone Trimethyllysine Binder Within The EED-EZH2 Polycomb Complex · the same entry in another collection · chain A against A, TM-score 1.00
O75530 · AlphaFold monomer V2.0 prediction for polycomb protein eed (O75530) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75530
Elsewhere: RCSB PDB 3JPX · PDBe 3JPX · UniProt O75530

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