MolNFT v1 · #6823 · protein

Structure of a major immunogenic site on foot-and-mouth disease virus

1FOD · Foot and mouth disease virus: “Structure of a major immunogenic site on foot-and-mouth disease virus”. X-ray diffraction, 9 pockets (best druggability 0.77). MolNFT v1 #6823 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1FOD
Type: protein
Length: 690 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Foot and mouth disease virus
UniProt: Q84771, P87677
Pockets: 9 · best druggability 0.77

Structure

x-ray diffraction · 4 distinct chains · 12% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
1	Foot and mouth disease virus	protein	210	17% helix, 28% strand	Q84771
2	Foot and mouth disease virus	protein	214	9% helix, 44% strand	Q84771
3	Foot and mouth disease virus	protein	220	8% helix, 33% strand	Q84771
4	Foot and mouth disease virus	protein	46	26% helix, 2% strand	P87677

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	946	0.77	0.79	92	empty
2	239	0.53	0.76	29	empty
3	195	0.52	0.77	28	empty
4	96	0.50	0.82	22	empty
5	112	0.47	0.79	20	empty

Interfaces

6 interfaces between chains.

1–2 · 2035 Å² buried · 37 hydrogen bonds · protein-protein
1–3 · 1355 Å² buried · 24 hydrogen bonds · protein-protein
2–3 · 993 Å² buried · 17 hydrogen bonds · protein-protein
1–4 · 816 Å² buried · 16 hydrogen bonds · protein-protein
2–4 · 262 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1FOD · Structure of a major immunogenic site on foot-and-mouth disease virus · the same entry in another collection · chain 1 against 1, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q84771
Every structure of UniProt P87677
Elsewhere: RCSB PDB 1FOD · PDBe 1FOD · UniProt Q84771 · UniProt P87677

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