MolNFT v1 · #68212 · protein
Cryo-EM structure of the magnesium channel cora in the magnesium-free, asymmetric open state II
3JCH · Magnesium transport protein cora: “Cryo-EM structure of the magnesium channel cora in the magnesium-free, asymmetric open state II”. Electron microscopy, 13 pockets (best druggability 0.63). MolNFT v1 #68212 on GenesisL1: 3D…
- PDB
- 3JCH
- Type
- protein
- Length
- 1,657 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Magnesium transport protein cora
- UniProt
- Q9WZ31
- Pockets
- 13 · best druggability 0.63
Structure
electron microscopy · 5 distinct chains · 55% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Magnesium transport protein cora | protein | 331 | 52% helix, 15% strand | Q9WZ31 |
| B | Magnesium transport protein cora | protein | 330 | 55% helix, 15% strand | Q9WZ31 |
| C | Magnesium transport protein cora | protein | 332 | 55% helix, 14% strand | Q9WZ31 |
| D | Magnesium transport protein cora | protein | 333 | 56% helix, 14% strand | Q9WZ31 |
| E | Magnesium transport protein cora | protein | 331 | 56% helix, 15% strand | Q9WZ31 |
Pockets
13 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 587 | 0.63 | 0.75 | 69 | empty |
| 2 | 607 | 0.59 | 0.73 | 72 | empty |
| 3 | 575 | 0.59 | 0.73 | 71 | empty |
| 4 | 537 | 0.58 | 0.74 | 73 | empty |
| 5 | 557 | 0.57 | 0.73 | 73 | empty |
Interfaces
5 interfaces between chains.
- B–C · 245 Ų buried · 2 hydrogen bonds · protein-protein
- D–E · 242 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 216 Ų buried · 1 hydrogen bond · protein-protein
- C–D · 213 Ų buried · 2 hydrogen bonds · protein-protein
- A–E · 191 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3JCH · Cryo-EM structure of the magnesium channel CorA in the magnesium-free, asymmetric open… · the same entry in another collection · chain E against E, TM-score 1.00
- Q9WZ31 · AlphaFold monomer V2.0 prediction for COBALT/MAGNESIUM transport protein cora (Q9WZ31) · a predicted model of the same protein · chain E against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WZ31
- Elsewhere: RCSB PDB 3JCH · PDBe 3JCH · UniProt Q9WZ31
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