MolNFT v1 · #68169 · protein
Heavy meromyosin from schistosoma mansoni muscle thick filament by negative stain EM
3JAX · Myosin 2 heavy chain: “Heavy meromyosin from schistosoma mansoni muscle thick filament by negative stain EM”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #68169 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3JAX
- Type
- protein
- Length
- 2,566 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin 2 heavy chain; Smooth muscle myosin essential light chain; Myosin regulatory light…
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 4 distinct chains · 48% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin 2 heavy chain | protein | 938 | 46% helix, 11% strand | — |
| B | Myosin 2 heavy chain | protein | 940 | 50% helix, 10% strand | — |
| C, D | Smooth muscle myosin essential light chain | protein | 148 | 54% helix, 7% strand | — |
| E, F | Myosin regulatory light chain | protein | 196 | 47% helix, 4% strand | — |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 662 | 0.82 | 0.86 | 67 | empty |
| 2 | 995 | 0.79 | 0.81 | 110 | empty |
| 3 | 85 | 0.77 | 0.98 | 22 | empty |
| 4 | 590 | 0.76 | 0.82 | 79 | empty |
| 5 | 969 | 0.75 | 0.78 | 88 | empty |
Interfaces
11 interfaces between chains.
- A–B · 5151 Ų buried · 59 hydrogen bonds · protein-protein
- B–F · 2589 Ų buried · 57 hydrogen bonds · protein-protein
- B–D · 2418 Ų buried · 37 hydrogen bonds · protein-protein
- A–E · 2322 Ų buried · 46 hydrogen bonds · protein-protein
- E–F · 1610 Ų buried · 45 hydrogen bonds · protein-protein
Compared structures
- 3JAX · Heavy meromyosin from Schistosoma mansoni muscle thick filament by negative stain EM · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3JAX · PDBe 3JAX
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