MolNFT v1 · #68155 · protein
Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine-bound state
3JAE · Glycine receptor subunit ALPHAZ1: “Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine-bound state”. Electron microscopy, 1 ligand (NAG), 20 pockets (best druggability 0.81). MolNFT v1 #68155…
- PDB
- 3JAE
- Type
- protein
- Length
- 1,690 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycine receptor subunit ALPHAZ1
- Ligands
- NAG
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 36% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Glycine receptor subunit ALPHAZ1 | protein | 338 | 36% helix, 28% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 10 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 641 | 0.81 | 0.86 | 106 | empty |
| 2 | 816 | 0.79 | 0.82 | 98 | empty |
| 3 | 843 | 0.77 | 0.81 | 84 | empty |
| 4 | 439 | 0.77 | 0.86 | 65 | empty |
| 5 | 401 | 0.76 | 0.85 | 63 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1767 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 1766 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 1764 Ų buried · 6 hydrogen bonds · protein-protein
- D–E · 1763 Ų buried · 6 hydrogen bonds · protein-protein
- A–E · 1736 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 3JAE · Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3JAE · PDBe 3JAE
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