MolNFT v1 · #68123 · protein

Fitting of Fab into the cryoem density MAP of EV71 procapsid in complex with FAB22A12

3J93 · Neutralizing antibody 22A12, light chain: “Fitting of Fab into the cryoem density MAP of EV71 procapsid in complex with FAB22A12”. Electron microscopy, 4 pockets (best druggability 0.52). MolNFT v1 #68123 on GenesisL1: 3D structure…

PDB: 3J93
Type: protein
Length: 434 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neutralizing antibody 22A12, light chain; Neutralizing antibody 22A12, heavy chain
Pockets: 4 · best druggability 0.52

Structure

electron microscopy · 2 distinct chains · 6% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Neutralizing antibody 22A12, light chain	protein	214	6% helix, 50% strand	—
H	Neutralizing antibody 22A12, heavy chain	protein	220	7% helix, 45% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	333	0.52	0.73	48	empty
2	127	0.42	0.75	18	empty
3	60	0.34	0.78	17	empty
4	82	0.31	0.72	19	empty

Interfaces

1 interface between chains.

L–H · 1889 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3J93 · Fitting of Fab into the cryoEM density map of EV71 procapsid in complex with Fab22A12 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3J93 · PDBe 3J93

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