MolNFT v1 · #68110 · protein
Model of the human EIF3 pci-mpn octamer docked into the 43S EM MAP
3J8C · Eukaryotic translation initiation factor 3 subunit a: “Model of the human EIF3 pci-mpn octamer docked into the 43S EM MAP”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #68110 on GenesisL1: 3D structure…
- PDB
- 3J8C
- Type
- protein
- Length
- 2,542 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit a; Eukaryotic translation initiation…
- EC
- 3.4.19.12
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 8 distinct chains · 66% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 3 subunit a | protein | 488 | 74% helix, 2% strand | — |
| C | Eukaryotic translation initiation factor 3 subunit C | protein | 546 | 68% helix, 2% strand | — |
| E | Eukaryotic translation initiation factor 3 subunit E | protein | 384 | 69% helix, 2% strand | — |
| F | Eukaryotic translation initiation factor 3 subunit F (EC 3.4.19.12) | protein | 232 | 46% helix, 25% strand | — |
| H | Eukaryotic translation initiation factor 3 subunit H | protein | 254 | 53% helix, 19% strand | — |
| K | Eukaryotic translation initiation factor 3 subunit K | protein | 204 | 72% helix, 1% strand | — |
| L | Eukaryotic translation initiation factor 3 subunit L | protein | 258 | 66% helix, 2% strand | — |
| M | Eukaryotic translation initiation factor 3 subunit M | protein | 176 | 72% helix, 5% strand | — |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 936 | 0.84 | 0.86 | 155 | empty |
| 2 | 1100 | 0.78 | 0.80 | 132 | empty |
| 3 | 909 | 0.77 | 0.80 | 147 | empty |
| 4 | 511 | 0.76 | 0.84 | 97 | empty |
| 5 | 550 | 0.75 | 0.83 | 83 | empty |
Interfaces
15 interfaces between chains.
- F–H · 987 Ų buried · 0 hydrogen bonds · protein-protein
- H–M · 511 Ų buried · 7 hydrogen bonds · protein-protein
- C–E · 465 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 437 Ų buried · 6 hydrogen bonds · protein-protein
- E–L · 398 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3J8C · Model of the human eIF3 PCI-MPN octamer docked into the 43S EM map · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3J8C · PDBe 3J8C
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