MolNFT v1 · #68098 · protein
Capsid expansion mechanism of bacteriophage T7 revealed by multi-state atomic models derived from cryo-EM reconstructions
3J7V · Major capsid protein 10A: “Capsid expansion mechanism of bacteriophage T7 revealed by multi-state atomic models derived from cryo-EM…”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #68098 on GenesisL1: 3D…
- PDB
- 3J7V
- Type
- protein
- Length
- 2,112 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major capsid protein 10A
- UniProt
- P19726
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 7 distinct chains · 27% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major capsid protein 10A | protein | 300 | 24% helix, 13% strand | P19726 |
| B | Major capsid protein 10A | protein | 309 | 27% helix, 8% strand | P19726 |
| C | Major capsid protein 10A | protein | 296 | 25% helix, 9% strand | P19726 |
| D | Major capsid protein 10A | protein | 298 | 29% helix, 12% strand | P19726 |
| E | Major capsid protein 10A | protein | 293 | 26% helix, 12% strand | P19726 |
| F | Major capsid protein 10A | protein | 299 | 30% helix, 12% strand | P19726 |
| G | Major capsid protein 10A | protein | 317 | 25% helix, 10% strand | P19726 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1074 | 0.85 | 0.86 | 134 | empty |
| 2 | 316 | 0.82 | 0.92 | 65 | empty |
| 3 | 874 | 0.81 | 0.83 | 97 | empty |
| 4 | 301 | 0.76 | 0.88 | 48 | empty |
| 5 | 1164 | 0.76 | 0.78 | 121 | empty |
Interfaces
11 interfaces between chains.
- E–F · 1585 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1512 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 1426 Ų buried · 6 hydrogen bonds · protein-protein
- A–F · 1379 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 1367 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 3J7V · Capsid Expansion Mechanism Of Bacteriophage T7 Revealed By Multi-State Atomic Models… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19726
- Elsewhere: RCSB PDB 3J7V · PDBe 3J7V · UniProt P19726
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