MolNFT v1 · #67993 · protein

The enterovirus 71 empty capsid

3J23 · Capsid protein VP1: “The enterovirus 71 empty capsid”. Electron microscopy, 8 pockets (best druggability 0.66). MolNFT v1 #67993 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3J23
Type: protein
Length: 694 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Capsid protein VP1; Capsid protein VP0; Capsid protein VP3
UniProt: B2ZUN0
Pockets: 8 · best druggability 0.66

Structure

electron microscopy · 3 distinct chains · 9% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Capsid protein VP1	protein	218	7% helix, 33% strand	B2ZUN0
B	Capsid protein VP0	protein	237	8% helix, 38% strand	B2ZUN0
C	Capsid protein VP3	protein	239	10% helix, 35% strand	B2ZUN0

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	317	0.66	0.81	34	empty
2	260	0.53	0.76	33	empty
3	121	0.49	0.80	25	empty
4	160	0.46	0.76	35	empty
5	76	0.40	0.79	19	empty

Interfaces

3 interfaces between chains.

A–C · 3103 Å² buried · 50 hydrogen bonds · protein-protein
A–B · 1823 Å² buried · 30 hydrogen bonds · protein-protein
B–C · 1560 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

3J23 · The Enterovirus 71 empty capsid · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B2ZUN0
Elsewhere: RCSB PDB 3J23 · PDBe 3J23 · UniProt B2ZUN0

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.