MolNFT v1 · #67987 · protein

Low affinity dynein microtubule binding domain - tubulin complex

3J1U · Cytoplasmic dynein 1 heavy chain 1, seryl T-RNA synthetase…: “Low affinity dynein microtubule binding domain - tubulin complex”. Electron microscopy, 15 pockets (best druggability 0.89). MolNFT v1 #67987 on GenesisL1: 3D structure…

PDB: 3J1U
Type: protein
Length: 1,030 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytoplasmic dynein 1 heavy chain 1, seryl T-RNA synthetase chimera; Tubulin alpha-1B…
UniProt: Q9JHU4
Pockets: 15 · best druggability 0.89

Structure

electron microscopy · 3 distinct chains · 49% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytoplasmic dynein 1 heavy chain 1, seryl T-RNA synthetase chimera	protein	164	77% helix, 0% strand	Q9JHU4
B	Tubulin alpha-1B chain	protein	439	42% helix, 12% strand	—
C	Tubulin beta-2B chain	protein	427	45% helix, 14% strand	—

Pockets

15 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1083	0.89	0.91	134	empty
2	841	0.88	0.90	118	empty
3	392	0.79	0.88	59	empty
4	437	0.79	0.87	44	empty
5	187	0.72	0.89	28	empty

Interfaces

3 interfaces between chains.

B–C · 1339 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 655 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 342 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

3J1U · Low affinity dynein microtubule binding domain - tubulin complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9JHU4
Elsewhere: RCSB PDB 3J1U · PDBe 3J1U · UniProt Q9JHU4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.