MolNFT v1 · #67952 · protein
Model of a 24MER alphab-crystallin multimer
3J07 · Alpha-crystallin B chain: “Model of a 24MER alphab-crystallin multimer”. Solid-state nmr; solution scattering; electron microscopy, 20 pockets (best druggability 0.76). MolNFT v1 #67952 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3J07
- Type
- protein
- Length
- 4,200 residues
- Chains
- 24
- Method
- solid-state nmr; solution scattering; electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-crystallin B chain
- UniProt
- P02511
- Pockets
- 20 · best druggability 0.76
Structure
solid-state nmr; solution scattering; electron microscopy · 1 distinct chain · 11% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | Alpha-crystallin B chain | protein | 175 | 11% helix, 22% strand | P02511 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1140 | 0.76 | 0.78 | 123 | empty |
| 2 | 747 | 0.74 | 0.79 | 95 | empty |
| 3 | 577 | 0.71 | 0.79 | 69 | empty |
| 4 | 610 | 0.70 | 0.79 | 61 | empty |
| 5 | 509 | 0.70 | 0.80 | 61 | empty |
Interfaces
102 interfaces between chains.
- T–U · 2729 Ų buried · 37 hydrogen bonds · protein-protein
- N–O · 2727 Ų buried · 36 hydrogen bonds · protein-protein
- H–I · 2704 Ų buried · 33 hydrogen bonds · protein-protein
- S–X · 2695 Ų buried · 36 hydrogen bonds · protein-protein
- B–C · 2693 Ų buried · 35 hydrogen bonds · protein-protein
Compared structures
- 3J07 · Model of a 24mer alphaB-crystallin multimer · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02511
- Elsewhere: RCSB PDB 3J07 · PDBe 3J07 · UniProt P02511
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