MolNFT v1 · #67900 · protein

Variable domains of the mouse Fab (1AIF) fitted into the cryoem reconstruction of the virus-Fab 16 complex

3IY5 · Antibody fragment IGG2A (light chain): “Variable domains of the mouse Fab (1AIF) fitted into the cryoem reconstruction of the virus-Fab 16 complex”. Electron microscopy, 3 pockets (best druggability 0.42). MolNFT v1 #67900 on…

PDB: 3IY5
Type: protein
Length: 230 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antibody fragment IGG2A (light chain); Antibody fragment IGG2A (heavy chain)
Pockets: 3 · best druggability 0.42

Structure

electron microscopy · 2 distinct chains · 4% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Antibody fragment IGG2A (light chain)	protein	108	3% helix, 40% strand	—
B	Antibody fragment IGG2A (heavy chain)	protein	122	5% helix, 39% strand	—

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	103	0.42	0.78	20	empty
2	96	0.34	0.73	16	empty
3	58	0.32	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 871 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3IY5 · Variable domains of the mouse Fab (1AIF) fitted into the cryoEM reconstruction of the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3IY5 · PDBe 3IY5

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