MolNFT v1 · #67852 · protein

Crystal structure of human copper homeostasis protein cutc

3IWP · Copper homeostasis protein cutc homolog: “Crystal structure of human copper homeostasis protein cutc”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #67852 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 3IWP
Type: protein
Length: 2,898 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Copper homeostasis protein cutc homolog
UniProt: Q9NTM9
Pockets: 20 · best druggability 0.81

Structure

x-ray diffraction · 12 distinct chains · 39% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Copper homeostasis protein cutc homolog	protein	249	39% helix, 18% strand	Q9NTM9
B	Copper homeostasis protein cutc homolog	protein	244	41% helix, 19% strand	Q9NTM9
C	Copper homeostasis protein cutc homolog	protein	247	40% helix, 19% strand	Q9NTM9
D	Copper homeostasis protein cutc homolog	protein	245	41% helix, 19% strand	Q9NTM9
E	Copper homeostasis protein cutc homolog	protein	242	38% helix, 19% strand	Q9NTM9
F	Copper homeostasis protein cutc homolog	protein	241	37% helix, 20% strand	Q9NTM9
G	Copper homeostasis protein cutc homolog	protein	237	40% helix, 21% strand	Q9NTM9
H	Copper homeostasis protein cutc homolog	protein	236	40% helix, 17% strand	Q9NTM9
I	Copper homeostasis protein cutc homolog	protein	241	41% helix, 20% strand	Q9NTM9
J	Copper homeostasis protein cutc homolog	protein	239	38% helix, 20% strand	Q9NTM9
K	Copper homeostasis protein cutc homolog	protein	238	38% helix, 19% strand	Q9NTM9
L	Copper homeostasis protein cutc homolog	protein	239	39% helix, 16% strand	Q9NTM9

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	958	0.81	0.83	90	empty
2	914	0.76	0.80	117	empty
3	528	0.76	0.83	69	empty
4	950	0.75	0.78	123	empty
5	861	0.73	0.77	93	empty

Interfaces

18 interfaces between chains.

C–D · 2651 Å² buried · 21 hydrogen bonds · protein-protein
A–B · 2580 Å² buried · 22 hydrogen bonds · protein-protein
K–L · 2437 Å² buried · 27 hydrogen bonds · protein-protein
E–F · 2429 Å² buried · 18 hydrogen bonds · protein-protein
I–J · 2219 Å² buried · 24 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

3IWP · Crystal structure of human copper homeostasis protein CutC · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NTM9
Elsewhere: RCSB PDB 3IWP · PDBe 3IWP · UniProt Q9NTM9

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