MolNFT v1 · #67661 · protein

Active site mutants of B. subtilis seca

3IQY · Protein translocase subunit seca: “Active site mutants of B. subtilis seca”. X-ray diffraction, 1 ligand (SO4), 12 pockets (best druggability 0.85). MolNFT v1 #67661 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3IQY
Type: protein
Length: 802 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein translocase subunit seca
UniProt: P28366
Ligands: SO4
Pockets: 12 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein translocase subunit seca	protein	802	51% helix, 10% strand	P28366

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1093	0.85	0.86	109	empty
2	57	0.69	0.96	23	empty
3	264	0.60	0.80	34	SO4
4	195	0.55	0.79	29	empty
5	268	0.54	0.76	33	empty

Compared structures

3IQY · Active site mutants of B. subtilis SecA · the same entry in another collection · chain A against A, TM-score 1.00
P28366 · AlphaFold monomer V2.0 prediction for protein translocase subunit seca (P28366) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28366
Elsewhere: RCSB PDB 3IQY · PDBe 3IQY · UniProt P28366

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